Composition of PentOS OI™ that is 100% derived from human bone.
Every batch used to manufacture PentOS OI™ products is verified to be osteoinductive and histologically demonstrates all five elements of bone formation.
- New bone
New bone is the final step in the maturation of the product.
- Bone marrow
The presence of bone marrow indicates the ability of the product to differentiate into osteoblasts, chondrocytes, cartilage and new bone.
Osteocytes are derived from osteoblasts, or bone forming cells, and are essentially osteoblasts surrounded by the products they secreted.
Cartilage is replaced by bone during ossification in the higher vertebrates. It is indicative that the bone formation is forthcoming.
A Chondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage formation and functionality. It arises from mesenchymal stem cells.
Osteoconduction provides the guidance, osteoinduction encourages the transformation of undifferentiated cells to active bone cells and osteogenesis, living osteoblasts within the graft material aid in the bone renovation process.
See our Successful Bone Graft article.